Penehyclidine Hydrochloride Pretreatment Ameliorates Rhabdomyolysis-Induced AKI by Activating the Nrf2/HO-1 Pathway and Alleviating [corrected] Endoplasmic Reticulum Stress in Rats. The.

Abstract

Acute kidney injury (AKI) is one of the most severe complications of rhabdomyolysis (RM). The underlying mechanisms and potential preventions need to be investigated. Penehyclidine hydrochloride (PHC) was reported to ameliorate renal ischemia-reperfusion injury, but the effect of PHC on RM-reduced AKI is unknown. In this study, we established a rat model of… (More)
DOI: 10.1371/journal.pone.0151158

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@article{Zhao2016PenehyclidineHP, title={Penehyclidine Hydrochloride Pretreatment Ameliorates Rhabdomyolysis-Induced AKI by Activating the Nrf2/HO-1 Pathway and Alleviating [corrected] Endoplasmic Reticulum Stress in Rats. The.}, author={Wei Zhao and Xudong Huang and Lixia Zhang and Xinjun Yang and Lihui Wang and Yunshuang Chen and Jinghua Wang and Guangli Wu}, journal={PloS one}, year={2016}, volume={11 3}, pages={e0151158} }