Pendrin modulates ENaC function by changing luminal HCO3-.

  title={Pendrin modulates ENaC function by changing luminal HCO3-.},
  author={Vladim{\'i}r Pech and Truyen Derek Pham and Seongun M. Hong and Alan M. Weinstein and Kathryn B. Spencer and Billy Jean Duke and Eric Walp and Young Hee Kim and Roy Lee Sutliff and Hui-Fang Bao and Douglas C. Eaton and Susan M. Wall},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={21 11},
The epithelial Na(+) channel, ENaC, and the Cl(-)/HCO(3)(-) exchanger, pendrin, mediate NaCl absorption within the cortical collecting duct and the connecting tubule. Although pendrin and ENaC localize to different cell types, ENaC subunit abundance and activity are lower in aldosterone-treated pendrin-null mice relative to wild-type mice. Because pendrin mediates HCO(3)(-) secretion, we asked if increasing distal delivery of HCO(3)(-) through a pendrin-independent mechanism "rescues" ENaC… CONTINUE READING
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