Penasins A-E, long-chain cytotoxic sphingoid bases, from a marine sponge Penares sp.

  title={Penasins A-E, long-chain cytotoxic sphingoid bases, from a marine sponge Penares sp.},
  author={Hideki Ando and Reiko Ueoka and Shigeru Okada and Tsuyoshi Fujita and Takashi Iwashita and Takaaki Imai and Tomoya Yokoyama and Yuji Matsumoto and Rob W. M. van Soest and Shigeki Matsunaga},
  journal={Journal of natural products},
  volume={73 11},
Five sphingoid bases, penasin A (1), penasin B (2), and a mixture of penasins C-E (3-5), were identified from a marine sponge Penares sp. as cytotoxic constituents. The structure of the common polar head part was assigned by analysis of the NMR data, whereas the structures of the long aliphatic chains including the locations of double bond(s) and a branched methyl group were determined by analysis of tandem FABMS and (13)C NMR data together with the GC-MS analysis of ozonolysis products. The… Expand
Isolation, structures, and biological activities of triterpenoids from a Penares sp. marine sponge.
  • S. A. Kolesnikova, Ekaterina G Lyakhova, +6 authors Valentin A Stonik
  • Biology, Medicine
  • Journal of natural products
  • 2013
Six new triterpenoids (1-6) and the previously known penasterone, acetylpenasterol, and ergosta-4,24(28)-dien-3-one were isolated from a Penares sp. sponge collected from Vietnamese waters.Expand
Secondary Metabolites of the Marine Sponge Penares cf. schulzei, Fluorescence Properties of 24-Methylenecholesta-4,6,8(14)-Trien-3-One
Marine sponges of the genus Penares are known as sources of various low-molecular-weight secondary metabolites including bioactive indoles, azetidine alkaloids [1], unusual triterpenoids [2, 3],Expand
Further study on Penares sp. from Vietnamese waters: Minor lanostane and nor-lanostane triterpenes
Eight new oxidized lanostane and nor-lanostane derivatives (1-8) along with the previously known penasterol (9) and 24-ethylcholesta-4,24(28)-dien-3-one (10) were isolated from a sponge Penares sp.Expand
Bromine-containing alkaloids from the marine sponge Penares sp.
Two new unusual alkaloids were isolated from the sponge Penares sp., collected from Viet Nam waters (the South China Sea). The structures of these compounds were established by analysis of 1D, 2D NMRExpand
Halisphingosines A and B, modified sphingoid bases from Haliclona tubifera. Assignment of configuration by circular dichroism and van't Hoff's principle of optical superposition.
The sensitive CD deconvolution method, applicable to submilligram samples, simultaneously predicted the relative and absolute configuration of three stereocenters in halisphingosine A with precision and accuracy. Expand
Isolation and structural characterization of four diastereomeric lignan glycosides from Abies holophylla and their neuroprotective activity
Abstract Diastereomers are a type of a stereoisomer and they are often isolated as a mixture due to their similar physical properties. Through HPLC technique, we isolated four stereoisomeric lignanExpand
Porifera (Sponges)–1
The article contains sections titled: Overview of the Universe of Sponges Metabolites of Calcarea (Calcareous Sponges) General Characteristics of Calcarea Fatty Acids Sterols Expand
Chloroalkene Dipeptide Isosteres as Peptidomimetics
In drug discovery, the development of “isosteres”, in which a part of molecules is changed to their mimetic, is required to enhance the activity of seed or lead compounds. Alkene-type dipeptideExpand
Marine natural products.
This review covers the literature published in 2010 for marine natural products, with 895 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. Expand
Marine Sponges – Molecular Biology and Biotechnology
Marine sponges, as well-recognized sources of novel marine natural products with varied applications, are the ideal target for the implementation of new technologies in the field of metagenomics. Expand