Penalized logistic regression for detecting gene interactions.

  title={Penalized logistic regression for detecting gene interactions.},
  author={Mee Young Park and Trevor J. Hastie},
  volume={9 1},
We propose using a variant of logistic regression (LR) with (L)_(2)-regularization to fit gene-gene and gene-environment interaction models. Studies have shown that many common diseases are influenced by interaction of certain genes. LR models with quadratic penalization not only correctly characterizes the influential genes along with their interaction structures but also yields additional benefits in handling high-dimensional, discrete factors with a binary response. We illustrate the… CONTINUE READING
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