Pemphigus and other diseases. Results of indirect intercellular immunofluorescence.

@article{Anderson1970PemphigusAO,
  title={Pemphigus and other diseases. Results of indirect intercellular immunofluorescence.},
  author={H. Anderson and V. Newcomer and J. Landau and L. Rosenthal},
  journal={Archives of dermatology},
  year={1970},
  volume={101 5},
  pages={
          538-46
        }
}
The intercellular pattern of fluorescence was demonstrated in 24 of 75 patients with diseases other than pemphigus. A relationship was found between the presence of anti-B isohemagglutinins and intercellular fluorescence as demonstrated by the indirect immunofluorescent (IIF) technique, using fetal rhesus monkey ( Macaca mulatta ) esophagus as the substrate. When the anti-B isohemagglutinin titer was reduced or abolished, after absorption with B substance, the intercellular pattern was reduced… Expand
Commentary: Clinical Importance of Autoantibodies in Pemphigus
TLDR
In the past 40 years, there have been great advances in the understanding of the bullous diseases, in general, and pemphigus, in particular, and Beutner and Jordon 1 initially observed that serum samples from patients with pemPHigus vulgaris contained an antibody that reacted with an intercellular substance of stratified squamous epithelium. Expand
Relationship between the serum autoantibody titers and the clinical activity of pemphigus vulgaris.
TLDR
Results indicate that serial pemphigus antibody titers may not be consistent enough to be used reliably as the sole guide for monitoring disease activity. Expand
FLUORESCENT ANTIBODY STUDIES OF PEMPHIGUS‐LIKE ANTIBODIES IN BURN SERA
TLDR
The reactions between bum sera and intercellular areas of monkey and guinea pig epithelial tissue were studied in greater detail and the use of fluorescein-labeled conjugates specific for the known human immunoglobulin classes were reported on. Expand
Indirect cutaneous immunofluorescence. I. Morphologic observations in bullous diseases, malignancies, and connective tissue diseases.
TLDR
Sera of 476 patients with bullous diseases, internal malignancies, and connective tissue diseases were tested for the bullous pemphigoid "band" and pemPHigus epidermal intercellular fluorescence by the indirect fluorescent antibody technique, which was found to be diagnostically extremely valuable. Expand
The correlation between the antibody titers in sera of patients with Pemphigus vulgaris and their clinical state.
TLDR
A positive correlation between the immunological findings and the clinical activity of the disease is indicated and in some cases, an exacerbation of the clinical state was associated with a rise in antibody titer. Expand
Cell and humoral immunity in endemic pemphigus foliaceus.
TLDR
It is concluded that cell immunity was preserved and that there was a relationship between antibody titers detected by the direct immunofluorescence test and extent of skin lesions and lesion intensity and course of lesions under treatment. Expand
Pemphigus and other diseases.
TLDR
These findings show that false positive patterns for pemphigus may be encountered in the IIF (indirect immunofluorescent) technique. Expand
Immunologic response to A and B erythrocytic antigen.
TLDR
Direct immunofluorescent studies showed IgG deposits in the intercellular spaces of the skin of the patients with pemphigus, however, C3 was found in the same sites in only three cases of pemPHigus erythematosus. Expand
Antibody-induced proteinase activation: A proposed mechanism for pemphigus
TLDR
Three different groups have presented results in two different experimental systems which indicate that subsequent to binding of pemphigus antibody to epidermal cells a proteinase is activated, which results in loss of cellular adhesion and acantholysis. Expand
Titers of passive cutaneous anaphylaxis antibody and clinical activity in pemphigus.
Titers of antibody detected in serum samples from patients with pemphigus detected by passive cutaneous anaphylaxis (PCA) were compared to the clinical activity of the disease process in 17 patients,Expand
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References

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AUTOANTIBODIES IN PEMPHIGUS VULGARIS: RESPONSE TO AN INTERCELLULAR SUBSTANCE OF EPIDERMIS.
TLDR
Antibodies to an intercellular substance of stratified squamous epithelium were detected by indirect immunofluorescent (IF) staining in the sera of eight out of 16 patients with pemphigus vulgaris and by direct IF staining of biopsies, γglobulin was demonstrated in the inter cellular areas of the epidermis. Expand
Immunofluorescent Studies of Autoantibodies to Intercellular Areas of Epithelia in Brazilian Pemphigus Foliaceus∗
Summary Sera of patients with fogo selvagem or BPF (Brazilian pemphigus foliaceus) were found to contain antibodies reactive with the intercellular areas of stratified squamous epithelium ofExpand
Fluorescent antibody studies in pemphigus vulgaris.
TLDR
Direct fluorescent antibody staining technique was employed to determine the presence of globulin and γ-globulin in biopsy sections and Tzanck preparations obtained from early bullous lesions of six patients with pemphigus vulgaris, finding the localization to be essentially in the cytoplasm of the epidermal cells, and particularly the acantholytic cells of the bullae. Expand
Clinical significance of autoantibodies in pemphigus.
TLDR
Serial determinations of antibodies by means of immunofluorescent (IF) staining were performed on the sera of 35 patients with pemphigus and there was a correlation between the level of antibody titers and the activity of the disease. Expand
Factors contributing to occasional failures in demonstration of pemphigus antibodies by the immunofluorescence test.
TLDR
In vivo binding of IgG to the intercellular areas can, however, be demonstrated in sections of biopsies of lesions even when the indirect staining fails to reveal the presence of pemphigus antibodies. Expand
Pemphigus Antigen and Blood Group Substances A and B
TLDR
Antiepithelial immunoglobulins (antibodies) in the sera of patients with the bullous skin disease pemphigus are revealed and these antibodies attach in vitro and in vivo to a component in stratified epithelia. Expand
Immunofluorescent studies in pemphigus vulgaris. Confirmatory observations and evaluation of technical considerations.
This study confirms the findings of Beutner and Jordan that patients with pemphigus vulgaris have circulating serum antibodies demonstrable by indirect immunofluorescent staining to the intercellularExpand
THE HISTOLOGICAL DISTRIBUTION OF BLOOD GROUP SUBSTANCES A AND B IN MAN
  • A. E. Szulman
  • Biology, Medicine
  • The Journal of experimental medicine
  • 1960
TLDR
The pancreas (exocrine portion) and the sweat glands were found to produce the antigen irrespectively of secretor status, and in non-secretors there was no identifiable antigen with the important exception of the deeper parts of gastric foveolae. Expand
The immunopathology of pemphigus and bullous pemphigoid.
This review article was prepared for the Journal of Investigative Dermatology by invitation. It is the first of a series of such articles which will appear in this journal in the months to come.Expand
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