Pemphigoid gestationis: early onset and blister formation are associated with adverse pregnancy outcomes

@article{Chi2009PemphigoidGE,
  title={Pemphigoid gestationis: early onset and blister formation are associated with adverse pregnancy outcomes},
  author={Ching-Chi Chi and S-H Wang and Robert Charles-Holmes and Christina M. Ambros-Rudolph and Jennifer Powell and Rachel E. Jenkins and M. Black and Fenella T. Wojnarowska},
  journal={British Journal of Dermatology},
  year={2009},
  volume={160}
}
Background  It is unclear whether clinical features of pemphigoid gestationis (PG), such as timing of onset and severity, may affect pregnancy outcomes or whether the adverse outcomes in pregnancies complicated by PG are related to or worsened by systemic corticosteroid treatment. 
Managing Pemphigoid Gestationis
Pemphigoid gestationis (PG) is important to diagnose and treat because it carries considerable morbidity for the pregnant woman and can also constitute a risk to the fetus. Herein, the treatmentExpand
Pemphigoid gestationis: current perspectives
TLDR
The pathogenesis, clinical characteristics, and management of pemphigoid gestationis are reviewed, which are associated with severe morbidity for pregnant women and carries fetal risks. Expand
Pemphigoid Gestationis and Fetal Outcomes
TLDR
In this retrospective analysis from England and Taiwan, researchers evaluated which clinical features in 61 pregnancies in 59 pemphigoid gestationis patients predicted poorer pregnancy outcomes. Expand
Pemphigoid Gestationis in a Third Trimester Pregnancy
TLDR
A case of pemphigoid gestationis occurring in a 33-year-old primigravida woman with symptoms of generalized pruritus is presented. Expand
Pemphigoid Gestationis in a Third Trimester Pregnancy F enol
Pemphigoid gestationis (PG) is a rare vesiculobullous dermatosis of pregnancy. It is commonly seen in second or third trimester. The diagnosis is frequently made with direct immunofluorescenceExpand
Pemphigoid gestationis: current management.
TLDR
The current management of Pemphigoid gestationis is discussed, an autoimmune blistering disease of pregnancy caused by autoantibodies directed against BP180 (type XVII collagen) in the basement membrane zone. Expand
Pemphigoid gestationis: pathogenesis and clinical features.
TLDR
The immunopathogenesis, diagnostic methods, and clinical features of Pemphigoid gestationis are discussed, which involves autoantibodies directed against type XVII collagen in the basement membrane zone. Expand
Case for diagnosis*
TLDR
The authors report a case of a 27-year-old woman at 28-weeks gestation with sudden onset of pruriginous vesicles and blisters in the abdomen and limbs. Expand
Dermatoses of Pregnancy
TLDR
Four major pregnancy-specific dermatoses are discussed: pemphigoid gestationis;Pruritic urticarial papules and plaques of pregnancy; prurigo ofregnancy; and pruritic folliculitis of pregnancy. Expand
Cyclosporine treatment in severe gestational pemphigoid.
TLDR
3 intractable cases of gestational pemphigoid treated with cyclosporine are reported, and it is reported that in more severe cases systemic immunosuppressive treatments are needed. Expand
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Pemphigoid gestationis is a rare autoimmune blistering disease of pregnancy. It is characterized by pruritic, urticarial plaques with the development of tense vesicles and bullae within the lesions.Expand
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TLDR
There was a significant increase in the frequency of infants that were ‘small for dates' and it follows that in pemphigoid gestationis the fetal prognosis is impaired. Expand
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Forty-one cases of immunologically proved herpes gestationis (HG) are reviewed and there appears to be an increased risk of fetal morbidity and mortality. The onset of HG is most frequent in theExpand
Clinical experience in pemphigoid gestationis: report of 10 cases.
TLDR
This condition can be easily confused with other dermatoses of pregnancy, for example, pruritic urticarial papules ofregnancy, and conservative treatment seems warranted. Expand
Fetal morbidity in herpes gestationis.
TLDR
All patients diagnosed with HG seen at the Hospital Clinic, Barcelona, Spain, between February 1972 and November 1994 were included and retrospectively studied; the issue of fetal complications was examined. Expand
Fetal risks in herpes gestationis.
TLDR
Herpes gestationis is associated with an increase in prematurity and small-for-gestational-age infants and the use of systemic steroids did not appear to influence risk. Expand
Herpes gestationis: clinical and histologic features of twenty-eight cases.
TLDR
Cases in which the characteristic vesiculobullous lesions of HG never developed were identified, and four women had urticarial papules or plaques throughout their clinical courses. Expand
A prospective study of 200 women with dermatoses of pregnancy correlating clinical findings with hormonal and immunopathological profiles
TLDR
This study indicates that all patients with specific dermatoses of pregnancy conformed well to the classification established by Holmes and Black in 1983, although the frequency of eczema in pregnancy is highlighted, to speculate as to possible causes. Expand
Immunopathology of the placenta in pemphigoid gestationis and linear IgA disease
TLDR
The results and previous immunogenetic studies suggest that PG may be unique among organ specific autoimmune disease, the autoantibodies forming during an allogeneic response rather than target cells behaving as antigen presenting cells. Expand
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TLDR
The present study supports that GCS do not represent a major teratogenic risk in humans and is powered to find a 2.5-fold increase in the overall rate of major anomalies. Expand
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