Pemoline Ingestion in Children: A Report of Five Cases and Review of the Literature

  title={Pemoline Ingestion in Children: A Report of Five Cases and Review of the Literature},
  author={Hidefumi Nakamura and Jeffrey L. Blumer and Michael D. Reed},
  journal={The Journal of Clinical Pharmacology},
The authors describe five pediatric cases of excessive pemoline ingestion. Based on their experience compared with previously reported cases in the literature, they describe the clinical presentation and rational treatment recommendations for acute pemoline ingestion. Overall, patients experienced a relatively benign clinical course following pemoline ingestion. Symptoms of pemoline ingestion appear to be primarily an accentuation of the drug's pharmacological effects on the central nervous and… 
3 Citations

Rhabdomyolysis: A Review of Clinical Presentation, Etiology, Diagnosis, and Management

This review article will focus on the presenting symptoms, the various etiologies, the underlying mechanisms, and the current management of pediatric rhabdomyolysis.



Pemoline Therapy Resulting in Liver Transplantation

With increasing evidence linking pemoline to liver failure, this agent should not be considered first-line therapy for ADHD and parents and patients should be educated on the signs and symptoms of liver toxicity.

Four cases of severe hepatotoxicity associated with pemoline: possible autoimmune pathogenesis.

Four cases of marked liver dysfunction in children on pemoline were encountered, two of these progressed to fulminant hepatic failure requiring liver transplantation and in those cases where autoantibodies were measured, there was evidence for autoimmune activation.

Amphetamine toxicity: experience with 127 cases.

Oral pemoline kinetics in hyperactive children

The time course of pemoline in plasma was investigated in seven prepubescent boys with attention‐deficit disorders who were hyperactive to explain the unpredictable nature of its dynamics and associated neurotoxicity in some cases.

Pemoline hepatotoxicity in children.

Pemoline-Induced Choreoathetosis and Rhabdomyolysis

A 49- year-old man who developed severe choreoathetosis with rhabdomyolysis after markedly increasing his intake of pemoline makes a complete recovery with supportive care.

Pemoline treatment of adolescents with attention deficit hyperactivity disorder: a short-term controlled trial.

Pemoline is well tolerated and effective in adolescents and may be a particularly useful ADHD treatment for adolescents, as reported in children and adults with ADHD.

Pemoline-induced Tourette's disorder: a case report.

  • D. Bachman
  • Medicine, Psychology
    The American journal of psychiatry
  • 1981
The author describes the case of a 14-year-old boy who developed Gilles de la Tourette's disorder during pemoline therapy and the boy's tics did not remit after the pem Caroline was discontinued.

Accidental Ingestion of Pemoline

1. Buntain WL, Isaacs H, Jr, Payne VC, Jr, Lindesmith GG, Rosenkrantz JG: Lobar emphysema, cystic adenomatoid malformation, pulmonary sequestration and bronchogenic cysts in infancy and childhood: a

Hyperthermia in psychostimulant overdose.