Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas.

@article{Rothbart2010PemetrexedIA,
  title={Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas.},
  author={Scott B Rothbart and Alexandra C Racanelli and Richard G. Moran},
  journal={Cancer research},
  year={2010},
  volume={70 24},
  pages={10299-309}
}
The chemotherapeutic drug pemetrexed, an inhibitor of thymidylate synthase, has an important secondary target in human leukemic cells, aminoimidazolecarboxamide ribonucleotide formyltransferase (AICART), the second folate-dependent enzyme of purine biosynthesis. The purine intermediate aminoimidazolecarboxamide ribonucleotide (ZMP), which accumulates behind this block, transmits an inhibitory signal to the mTORC1 complex via activation of the cellular energy sensor AMP-activated kinase (AMPK… CONTINUE READING
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