Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck

@article{Pivot2001PemetrexedDI,
  title={Pemetrexed disodium in recurrent locally advanced or metastatic squamous cell carcinoma of the head and neck},
  author={Xavier Pivot and Eric Raymond and Brigitte Laguerre and Marian Degardin and Laurent Cals and J P Armand and Jean Louis Lefebvre and Daniel G{\'e}douin and Veronique Ripoche and Louis Kayitalire and Clet Niyikiza and Robert B. Johnson and Jane E. Latz and Maurice Schneider},
  journal={British Journal of Cancer},
  year={2001},
  volume={85},
  pages={649 - 655}
}
This phase II study determined response rate of patients with locally advanced or metastatic head and neck cancer treated with pemetrexed disodium, a new multitargeted antifolate that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyl transferase. 35 patients with local or metastatic relapse of squamous cell carcinoma of the head and neck (31 male, 4 female; median age 53 years) were treated with pemetrexed 500 mg m2administered as a 10-minute infusion… CONTINUE READING

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