Pem homeobox gene regulatory sequences that direct androgen-dependent developmentally regulated gene expression in different subregions of the epididymis.

@article{Rao2002PemHG,
  title={Pem homeobox gene regulatory sequences that direct androgen-dependent developmentally regulated gene expression in different subregions of the epididymis.},
  author={Manjeet K. Rao and Chad Michael Wayne and Miles F Wilkinson},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 50},
  pages={
          48771-8
        }
}
The epididymis is a useful model system to understand the mechanisms that govern region-specific gene expression, as many gene products display spatially restricted expression within this organ. However, surprisingly little is known about how this regulation is achieved. Here, we report regulatory sequences from the Pem homeobox gene that drive expression in different subregions of the mouse epididymis in vivo. We found that the 0.3-kb 5'-flanking sequence (region I) from the Pem proximal… CONTINUE READING
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