Peloruside A Does Not Bind to the Taxoid Site on -Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines

Abstract

Peloruside A (peloruside), a microtubule-stabilizing agent from a marine sponge, is less susceptible than paclitaxel to multidrug resistance arising from overexpression of the P-glycoprotein efflux pump and is not affected by mutations that affect the taxoid binding site of -tubulin. In vitro studies with purified tubulin indicate that peloruside directly… (More)

Topics

5 Figures and Tables

Cite this paper

@inproceedings{Gaitanos2004PelorusideAD, title={Peloruside A Does Not Bind to the Taxoid Site on -Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines}, author={Thomas N Gaitanos and Rub{\'e}n M Buey and Javier D{\'i}az and J. Fernando Dı́az and Peter T. Northcote and Paul H Teesdale-Spittle and Jos{\'e} M Andreu and John H. Miller}, year={2004} }