Pellet manufacturing by extrusion-spheronization using process analytical technology


The aim of this study was to investigate the phase transitions occurring in nitrofurantoin and theophylline formulations during pelletization by extrusion-spheronization. An at-line process analytical technology (PAT) approach was used to increase the understanding of the solid-state behavior of the active pharmaceutical ingredients (APIs) during… (More)
DOI: 10.1208/pt060226


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