Pellagra: a review with emphasis on photosensitivity

@article{Wan2011PellagraAR,
  title={Pellagra: a review with emphasis on photosensitivity},
  author={Pengjie Wan and S. Moat and A V Anstey},
  journal={British Journal of Dermatology},
  year={2011},
  volume={164}
}
Niacin has recently been demonstrated to lower blood pressure in hypertensive patients and to reduce cardiovascular events when combined with a statin. As a consequence, niacin has been elevated from being of historical interest as the treatment for pellagra, to being a compound with possible relevance to contemporary therapeutics. In spite of this, niacin deficiency leading to pellagra continues to be a health problem in some countries. Characterized by an exposed‐site hyperpigmented… Expand
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References

SHOWING 1-10 OF 180 REFERENCES
Pellagra: a still existing disease
TLDR
Pellagra is no longer the medico-social problem it was in the past but in countries with a low nutritional level it continues to a considerable degree in endemic form and in areas of the so-called 'civilized world' where nutritional problems do not really exist, occasional cases are found. Expand
Pellagra may be a rare secondary complication of anorexia nervosa: a systematic review of the literature.
TLDR
Although pellagra appears to be a rare, yet possible secondary complication of anorexia nervosa, it should be considered in the work-up of patients who exhibit cutaneous manifestations subsequent to sunlight exposure. Expand
Rapid resolution of delusional parasitosis in pellagra with niacin augmentation therapy.
TLDR
A case of pellagra manifesting with delusional parasitosis in a man whose delusion resolved rapidly after he started niacin-augmentation therapy is reported, which may provide clues to the biological underpinnings of delusional Parasitosis as well as niacIn treatment as treatment option in similar cases. Expand
Joseph Goldberger's research on the prevention of pellagra
  • A. Morabia
  • Medicine
  • Journal of the Royal Society of Medicine
  • 2008
TLDR
It was discovered that pellagra was caused by a deficiency of the B vitamin niacin (nicotinic acid), and epidemiological and clinical research done by Joseph Goldberger and his colleagues had identified thatpellagra could be prevented by improved diet. Expand
PELLAGRA: WITH SPECIAL REFERENCE TO THE SKIN AND MUCOUS MEMBRANE
TLDR
A study was made of 125 cases of pellagra, occurring in the John Sealy Hospital in Galveston, special attention being paid to the conditions of the skin and mucous membrane. Expand
[Dose-dependent pellagroid skin reaction caused by carbamazepine].
TLDR
Interactions of carbamazepine with the vitamin B6- nicotinamide metabolism are the reason for these previously undescribed cutaneous side effects in connection with carbamazepsine therapy. Expand
The diagnostic importance of photosensitivity dermatoses in chronic alcoholism: report of two cases.
TLDR
The report highlights the fact that all physicians should be alerted to photosensitivity dermatoses in alcoholics; early treatment with multiple vitamin therapy, including nicotinic acid should be initiated in these patients. Expand
Pellagra: Dermatitis, dementia, and diarrhea
TLDR
The findings of this once mysterious disorder, one that still challenges clinicians world‐wide, are reviewed. Expand
Pellagra and pellagralike dermatoses: etiology, differential diagnosis, dermatopathology, and treatment.
TLDR
Clinical pellagra should be considered in the differential diagnosis of patients with chronic alcoholism, malnutrition, and amino acid imbalance, although most pellagrins respond to niacin combined with a high-protein diet, although other concomitant vitamin deficiencies may prevent the use of niacIn. Expand
Pellagra and pellagralike dermatoses: etiology, differential diagnosis, dermatopathology, and treatment.
TLDR
Clinical pellagra should be considered in the differential diagnosis of patients with chronic alcoholism, malnutrition, and amino acid imbalance, although other concomitant vitamin deficiencies may prevent the use of niacin. Expand
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