Pegylation of proteins and bioactive substances for medical and technical applications

  title={Pegylation of proteins and bioactive substances for medical and technical applications},
  author={Y. Kodera and A. Matsushima and M. Hiroto and H. Nishimura and A. Ishii and T. Ueno and Y. Inada},
  journal={Progress in Polymer Science},
Aplicabilidade do antígeno tetânico conjugado com derivados do Monometoxi-polietilenoglicol.
PRADO, S. M. A. Applicability of Tetanus Antigen Conjugated to Derivatives of Monometoxypolyethylene Glycol. 143 f. Ph. D. Thesis (Biotechnology) Instituto de Ciencias Biomedicas da Universidade deExpand
Well-defined protein–polymer conjugates—synthesis and potential applications
This article focuses on the synthetic pathways that have or can be utilized to specifically couple proteins to polymers and the different categories of well-defined protein–polymer conjugates and the effect of the polymer on the protein function are discussed. Expand
A novel diclofenac-hydrogel conjugate system for intraarticular sustained release: Development of 2-pyridylamino-substituted 1-phenylethanol (PAPE) and its derivatives as tunable traceless linkers.
A novel linker system is developed for diclofenac, a non-steroidal anti-inflammatory drug, for use in a polymer-conjugate depot system to minimize the production of undesired lactam side-products. Expand
Site-specific protein PEGylation catalyzed by endo-β-N-acetylglucosaminidase
Abstract We demonstrated a novel site-specific method of protein PEGylation that is catalyzed by endo-β-N-acetylglucosaminidase (ENGase) with PEGylated oxazoline (1) as a donor. PEGylation viaExpand
PEGylated Cationic Serum Albumin for Boosting Retroviral Gene Transfer
This work generated cationic human serum albumin protected by a shell of poly(ethylene glycol) (PEG); this significantly enhanced retroviral gene transduction with potentially attractive pharmacokinetics and low immunogenicity, and identified a very potent enhancer that boosted the transduction rates of viral vectors. Expand
Formulation and in vitro release studies of pegylated mucin based matrix tablets.
Pegylated mucin base will find useful application in the development of a wide range of formulations and has shown best flow with Acetylsalicylic acid (ASA) and Chloroquine Phosphate (CQ) granules. Expand
Self-assembled Nanoparticles Prepared from Tasar Antherea mylitta Silk Sericin
Silk sericin is the gum-like protein surrounding the fibroin in silk fibers, and generally it is removed during the fiber processing to produce fabrics. Like other silk proteins, the silk of tasarExpand