Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity.

@article{Elinav2009PegylatedLA,
  title={Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity.},
  author={Eran Elinav and Leonora Niv-Spector and Meirav N. Katz and Tulin Otamis Price and Mohammed Hadi Ali and Michal Yacobovitz and Gili Solomon and Shay Reicher and Jessica L. Lynch and Zamir Halpern and W. A. Banks and Arieh Gertler},
  journal={Endocrinology},
  year={2009},
  volume={150 7},
  pages={
          3083-91
        }
}
  • Eran Elinav, Leonora Niv-Spector, +9 authors Arieh Gertler
  • Published in Endocrinology 2009
  • Medicine, Biology
  • Leptin, a pleiotropic adipokine, is a central regulator of appetite and weight and a key immunomodulatory protein. Although inborn leptin deficiency causes weight gain, it is unclear whether induced leptin deficiency in adult wild-type animals would be orexigenic. Previous work with a potent competitive leptin antagonist did not induce a true metabolic state of leptin deficiency in mice because of a short circulating half-life. In this study, we increased the half-life of the leptin antagonist… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 55 CITATIONS, ESTIMATED 30% COVERAGE

    Drug targeting of leptin resistance.

    VIEW 20 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Modulation of intestinal L-glutamate transport by luminal leptin

    VIEW 4 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    The role of leptin in the regulation of glucose homeostasis

    VIEW 6 EXCERPTS
    CITES BACKGROUND & METHODS
    HIGHLY INFLUENCED

    20 years of leptin: insights into signaling assemblies of the leptin receptor.

    VIEW 2 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    Pegylated leptin antagonist with strong orexigenic activity in mice is not effective in chickens.

    VIEW 8 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    2009
    2019

    CITATION STATISTICS

    • 7 Highly Influenced Citations

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 56 REFERENCES

    Mechanisms of leptin action and leptin resistance.

    VIEW 1 EXCERPT

    Mechanismsofdisease : cytokine and adipokine signaling in uremic cachexia

    • CheungW MakRH, MarksDL ConeRD
    • Nat Clin Pract Nephrol
    • 2006

    The CNS as a target for peptides and peptide-based drugs.

    VIEW 1 EXCERPT

    Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists

    • Niv-SpectorL, Gonen-BergerD, +9 authors A Gertler
    • Biochem J 391:221–230
    • 2005
    VIEW 1 EXCERPT