Pegylated human recombinant leptin (PEG-OB) causes additional weight loss in severely energy-restricted, overweight men.

Abstract

BACKGROUND Increasing evidence suggests that falling leptin concentrations observed during fasting act as a peripheral signal of starvation, which serves to conserve energy in the face of limited reserves. An extension of this hypothesis is that exogenous leptin should affect energy regulation during severe energy restriction. OBJECTIVE To explore this… (More)

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@article{Hukshorn2003PegylatedHR, title={Pegylated human recombinant leptin (PEG-OB) causes additional weight loss in severely energy-restricted, overweight men.}, author={Chris J Hukshorn and Margriet S. Westerterp-Plantenga and Wim H. M. Saris}, journal={The American journal of clinical nutrition}, year={2003}, volume={77 4}, pages={771-6} }