Pegylated human interferon alpha 2a does not induce depression-associated changes in mice.

@article{Kosel2011PegylatedHI,
  title={Pegylated human interferon alpha 2a does not induce depression-associated changes in mice.},
  author={Markus Kosel and Andras Bilkei-Gorzo and Rainer Zawatzky and Andreas Zimmer and Thomas E. Schlaepfer},
  journal={Psychiatry research},
  year={2011},
  volume={185 1-2},
  pages={243-7}
}
Interferon (IFN) alpha proteins are proinflammatory cytokines having immunomodulating and antiviral properties. States during which cytokine systems are activated (e.g., during viral infection or during treatment of chronic hepatitis C and various malignancies with IFN alpha, etc.) can be associated with depression-like syndromes or even full-blown depressive episodes. Therefore, the role of IFN alpha and other cytokines in the pathogenesis of depressive disorder ("cytokine hypothesis of… CONTINUE READING

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