Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen.

@article{Selis2016PegylatedTF,
  title={Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen.},
  author={Fabio Selis and Giuseppina Foc{\`a} and Annamaria Sandomenico and Carla Marra and Concetta Di Mauro and Gloria Saccani Jotti and Silvia Scaramuzza and Annalisa Politano and Riccardo Sanna and Menotti Ruvo and Giancarlo Tonon},
  journal={International journal of molecular sciences},
  year={2016},
  volume={17 4},
  pages={491}
}
PEGylation of biomolecules is a major approach to increase blood stream half-life, stability and solubility of biotherapeutics and to reduce their immunogenicity, aggregation potential and unspecific interactions with other proteins and tissues. Antibodies have generally long half-lives due to high molecular mass and stability toward proteases, however their size lowers to some extent their potential because of a reduced ability to penetrate tissues, especially those of tumor origin. Fab or… CONTINUE READING
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