Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression.

@article{Chen2004PegylatedAP,
  title={Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression.},
  author={Xiaoyuan Chen and Yingping Hou and Michel Tohme and Ryan Park and Vazgen Khankaldyyan and Ignacio Gonzales-Gomez and James R. Bading and Walter E. Laug and Peter S. Conti},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2004},
  volume={45 10},
  pages={1776-83}
}
UNLABELLED The alphav-integrins, cell adhesion molecules that are highly expressed on activated endothelial cells and tumor cells but not on dormant endothelial cells or normal cells, present an attractive target for tumor imaging and therapy. We previously coupled a cyclic Arg-Gly-Asp (RGD) peptide, c(RGDyK), with 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA) and labeled the RGD-DOTA conjugate with 64Cu (half-life, 12.8 h; 19% beta+) for solid tumor targeting, with high… CONTINUE READING

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