Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for treatment of HIV/HCV co-infected patients.

@article{Laguno2004PeginterferonAP,
  title={Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for treatment of HIV/HCV co-infected patients.},
  author={Montserrat Laguno and Javier Murillas and Jos{\'e} L Blanco and Esteban Mart{\'i}nez and Rosa Miquel and J M S{\'a}nchez-Tapias and Xavier Bargall{\'o} and {\'A}ngeles Garc{\'i}a-Criado and Elisa de Lazzari and Mar{\'i}a Larrousse and Agathe Le{\'o}n and Montserrat Lonc{\'a} and Ana Milinkovi{\'c} and Josep Ma Gatell and Jos{\'e}p Mallolas},
  journal={AIDS},
  year={2004},
  volume={18 13},
  pages={F27-36}
}
BACKGROUND Current therapies for chronic hepatitis C virus (HCV) in HIV co-infected patients have a low success rate and are poorly tolerated. We have evaluated the efficacy and safety of interferon alfa-2b (IFN) + ribavirin (RBV) versus pegylated interferon alfa-2b (PEG-INF) + RBV. METHODS Randomized, single-centre, open-label clinical trial including patients with: detectable HCV-RNA, alanine aminotransferase > 1.5-fold upper limit of normal, abnormal liver histology, CD4 cell count > 250 x… CONTINUE READING
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