Peginterferon alfa-2a (40 kilodaltons) and ribavirin in patients with chronic hepatitis C and normal aminotransferase levels.

@article{Zeuzem2004PeginterferonA,
  title={Peginterferon alfa-2a (40 kilodaltons) and ribavirin in patients with chronic hepatitis C and normal aminotransferase levels.},
  author={Stefan Zeuzem and Mois{\'e}s Diago and Edward J. Gane and K Rajender Reddy and Paul J. Pockros and Daniele Prati and Mitchell L. Shiffman and Patrizia Farci and N. Gitlin and Christopher B O'brien and François Lamour and Pilar Lardelli},
  journal={Gastroenterology},
  year={2004},
  volume={127 6},
  pages={1724-32}
}
BACKGROUND & AIMS Patients with chronic hepatitis C and persistently normal alanine aminotransferase (ALT) levels have been routinely excluded from large randomized treatment trials; consequently, the efficacy and safety of antiviral therapy in this population are unknown. METHODS Patients with at least 3 normal ALT values over an 18-month period were randomized (3:3:1) to treatment with peginterferon alfa-2a 180 mug/wk plus ribavirin 800 mg/day for 24 weeks (212 patients), the same… CONTINUE READING
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