Pegfilgrastim-Induced Bone Pain: A Review on Incidence, Risk Factors, and Evidence-Based Management

@article{Moore2017PegfilgrastimInducedBP,
  title={Pegfilgrastim-Induced Bone Pain: A Review on Incidence, Risk Factors, and Evidence-Based Management},
  author={Donald C. Moore and Annie Pellegrino},
  journal={Annals of Pharmacotherapy},
  year={2017},
  volume={51},
  pages={797 - 803}
}
Objective: To review the incidence, risk factors, and management of pegfilgrastim-induced bone pain (PIBP). Data Sources: PubMed was searched from 1980 to March 31, 2017, using the terms pegfilgrastim and bone pain. Study Selection and Data Extraction: English-language, human studies and reviews assessing the incidence, risk factors, and management of PIBP were incorporated. Data Synthesis: A total of 3 randomized, prospective studies and 2 retrospective studies evaluated pharmacological… 

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TLDR
Pegfilgrastim is commonly used for primary prophylaxis during the first cycle of chemotherapy, and loratadine was the most commonly employed medication to mitigate this adverse effect.

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TLDR
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TLDR
It is demonstrated that naproxen at a dose of 500 mg twice per day is effective in reducing the incidence and severity of pegfilgrastim-induced bone pain.

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TLDR
The first case report in which loratadine prophylaxis completely alleviated NSAID-resistant severe pain secondary to pegfilgrastim is presented, showing that lor atadine may be a promising option for severe, resistant pegfilGrastim-induced bone pain.

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TLDR
Potential risk factors for bone pain in patients receiving myelosuppressive chemotherapy and primary prophylactic pegfilgrastim identified in this study are younger age and history of bone pain.

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TLDR
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TLDR
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TLDR
Mild-to-moderate bone pain is the most commonly reported adverse event associated with PEG and N (an NSAID) and L (an antihistamine) are used in the clinic to reduce this AE.