Pegfilgrastim-Induced Bone Pain: A Review on Incidence, Risk Factors, and Evidence-Based Management

  title={Pegfilgrastim-Induced Bone Pain: A Review on Incidence, Risk Factors, and Evidence-Based Management},
  author={Donald C. Moore and Annie Pellegrino},
  journal={Annals of Pharmacotherapy},
  pages={797 - 803}
Objective: To review the incidence, risk factors, and management of pegfilgrastim-induced bone pain (PIBP). Data Sources: PubMed was searched from 1980 to March 31, 2017, using the terms pegfilgrastim and bone pain. Study Selection and Data Extraction: English-language, human studies and reviews assessing the incidence, risk factors, and management of PIBP were incorporated. Data Synthesis: A total of 3 randomized, prospective studies and 2 retrospective studies evaluated pharmacological… 

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It is demonstrated that the occurrence of bone pain was similar with FIL and PEG-F, and the incidence of neutropenia and febrile neutropania was higher in FIL compared to P EG-F.

Efficacy of Plinabulin vs Pegfilgrastim for Prevention of Chemotherapy-Induced Neutropenia in Adults With Non-Small Cell Lung Cancer: A Phase 2 Randomized Clinical Trial.

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Title Oral loratadine in the management of G-CSF induced bone pain: a pilot study

Oral loratadine in the management of G-CSFinduced bone pain: a pilot study.

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The combination therapy with Peg G and mFFX markedly prolonged the progression-free survival compared with the non-Peg G group, and its effects were associated with a reduced incidence of neutropenic events as well as lower rates of dosage reduction, delayed chemotherapy due to neutropic events and altered blood cell counts after chemotherapy.



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Administration of prophylactic loratadine does not decrease the incidence of severe bone pain or improve quality of life in a high-risk patient population.

Prevention of pegfilgrastim-induced bone pain: a phase III double-blind placebo-controlled randomized clinical trial of the university of rochester cancer center clinical community oncology program research base.

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Empiric dose reduction of pegfilgrastim in breast cancer patients receiving cytotoxic chemotherapy

Empiric dose reduction from 6mg to 4mg administered on the day after chemotherapy was used to ameliorate pain while maintaining count recovery in patients who had empiric dose reductions because of bone pain with concomitant normal or high leukocyte counts during recovery.

Prevention of granulocyte-colony stimulating factor (G-CSF) induced bone pain using double histamine blockade

The use of a double histamine blockade is an inexpensive, safe, and effective way to alleviate bone pain symptoms secondary to G-CSF agents.