Pegademase bovine (PEG-ADA) for the treatment of infants and children with severe combined immunodeficiency (SCID)

@inproceedings{Booth2009PegademaseB,
  title={Pegademase bovine (PEG-ADA) for the treatment of infants and children with severe combined immunodeficiency (SCID)},
  author={Claire Booth and Hubert Bobby Gaspar},
  booktitle={Biologics : targets & therapy},
  year={2009}
}
Adenosine deaminase deficiency (ADA) is a rare, inherited disorder of purine metabolism characterized by immunodeficiency, failure to thrive and metabolic abnormalities. A lack of the enzyme ADA allows accumulation of toxic metabolites causing defects of both cell mediated and humoral immunity leading to ADA severe combined immune deficiency (SCID), a condition that can be fatal in early infancy if left untreated. Hematopoietic stem cell transplant is curative but is dependent on a good donor… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 46 references

Combined immune deficiencies due to purine enzyme defects

MS Hershfield
Philadelphia: WB Saunders; • 2004
View 4 Excerpts
Highly Influenced

Immunodeficiency diseases caused by adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency

M Hershfield, BS Mitchell
2001
View 6 Excerpts
Highly Influenced

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