Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families

  title={Peg3 Mutational Effects on Reproduction and Placenta-Specific Gene Families},
  author={Joomyeong Kim and Wesley D. Frey and Hongzhi He and Hana Kim and Muhammad Badre Ekram and Arundhati Bakshi and Mohammad Faisal and Bambarendage P. U. Perera and An Ye and Ryoichi Teruyama},
  booktitle={PloS one},
Peg3 (paternally expressed gene 3) is an imprinted gene encoding a DNA-binding protein. This gene plays important roles in controlling fetal growth rates and nurturing behaviors. In the current study, a new mutant mouse model has been generated to further characterize the functions of this DNA-binding protein. Besides known phenotypes, this new mutant model also revealed potential roles of Peg3 in mammalian reproduction. Female heterozygotes produce a much smaller number of mature oocytes than… CONTINUE READING
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by loss of heterozygosity and promoter methylation

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