Pefloxacin-induced achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen.

@article{Simonin2000PefloxacininducedAT,
  title={Pefloxacin-induced achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen.},
  author={M A Simonin and Pascale Gegout-Pottie and A. Minn and Pierre Gillet and Patrick Netter and Bernard Terlain},
  journal={Antimicrobial agents and chemotherapy},
  year={2000},
  volume={44 4},
  pages={867-72}
}
Despite a relatively low incidence of serious side effects, fluoroquinolones and the fluoroquinolone pefloxacin have been reported to occasionally promote tendinopathy that might result in the complication of spontaneous rupture of tendons. In the present study, we investigated in rodents the intrinsic deleterious effect of pefloxacin (400 mg/kg of body weight) on Achilles tendon proteoglycans and collagen. Proteoglycan synthesis was determined by measurement of in vivo and ex vivo radiosulfate… CONTINUE READING
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