Peering through the Windows of the Brain

@article{Gross1987PeeringTT,
  title={Peering through the Windows of the Brain},
  author={Paul M. Gross and Adolf Weindl and Karl M. Knigge},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={1987},
  volume={7},
  pages={663 - 672}
}
These seven specialized circumventricular structures of the mammalian brain represent windows with individualized structural characteristics permitting intimate contact between blood and cerebrospinal fluid, neurones and specialized ependyma-glia. These “Seven Windows of the Brain”, like the seven lucky deities of Japan, may each have a specific patron of body -brain function which they serve.1 

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References

SHOWING 1-10 OF 101 REFERENCES
The subfornical organ as a model of neurohumoral integration
  • P. Gross
  • Medicine, Biology
  • Brain Research Bulletin
  • 1985
TLDR
Evidence identifying the subfornical organ as a "neuroendocrine transducer" is summarized in categories based on its structure-function relationships with systemic blood, cerebrospinal fluid, and its afferent and efferent neural connections. Expand
Electrophysiology of the subfornical organ and its hypothalamic connections—an in-vivo study in the rat
TLDR
Observations provide initial evidence of functional connectivity of subfornical organ neurons with other hypothalamic cells that are engaged in central regulation of pituitary secretions and autonomic activities. Expand
Ultrastructure of the ventricular walls. Three-dimensional study of regional specialization.
TLDR
The scanning electron microscopic observation of regional structural specialization in the ventricular surface thus seems to support the concept of regional functional specialization. Expand
The periventricular anteroventral third ventricle (AV3V): Its relationship with the subfornical organ and neural systems involved in maintaining body fluid homeostasis
  • A. Johnson
  • Biology, Medicine
  • Brain Research Bulletin
  • 1985
TLDR
A model is presented proposing that specific structures within the AV3V function to integrate information derived from blood-borne angiotensin II (via the SFO) with input arising from vascular pressure/volume receptors, important for the generation of a normal component of thirst associated with extracellular dehydration. Expand
The subfornical organ.
TLDR
This chapter discusses the subfornical organ (SFO), a small, almost hemispherical or ovoid tubercle that protrudes into the lumen of the third ventricle at the level of the interventricular foramina in vertebrates. Expand
Bi-directional, chemically specified neural connections between the subfornical organ and the midbrain raphe system
  • R. Lind
  • Biology, Medicine
  • Brain Research
  • 1986
TLDR
It is suggested that the serotonergic-raphe projection to the SFO may participate in the relay of visceral sensory information, perhaps related to blood pressure, from the nucleus of the solitary tract and the lateral parabrachial nucleus. Expand
The circumventricular organs of the mammalian brain with special reference to monoaminergic innervation.
TLDR
This chapter discusses the circumventricular organs (CVO) of the mammalian brain with special reference to monoaminergic innervation, indicating a possible neurohormonal release of 5-HT into the CSF that may influence still unknown target cells. Expand
Ultrastructural localization of monoamines and peptides in rat area postrema.
An overall schema for the synaptic interactions of monoaminergic and peptidergic neurons and their relation to the ventricle and to blood vessels within the rat area postrema is presented. TheExpand
Differences in function and structure of the capillary endothelium in gray matter, white matter and a circumventricular organ of rat brain.
TLDR
Structural evidence for high rates of solute flux across the capillary endothelial cells in the subfornical organ of circumventricular organs is presented. Expand
Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat
TLDR
The subnuclear organization of PB is demonstrated, and this with the origins of its efferent connections, and recent immunohistochemical observations suggest that the subnuclear organizations of PB afferent and efferent connection may reflect, at least in part, their biochemical specificity. Expand
...
1
2
3
4
5
...