Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family?

@article{MenaSegovia2004PedunculopontineNA,
  title={Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family?},
  author={J. Mena-Segovia and J. Bolam and P. Magill},
  journal={Trends in Neurosciences},
  year={2004},
  volume={27},
  pages={585-588}
}
The basal ganglia are more highly interconnected with the pedunculopontine tegmental nucleus (PPN) than with any other brain region. Regulation and relay of basal ganglia activity are two key functions of the PPN. The PPN provides an interface for the basal ganglia to influence sleep and waking, and the two structures are similarly implicated in learning, reward and other cognitive functions. Perturbations of basal ganglia activity have consequences for the PPN and vice versa, exemplified by… Expand

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ConditionsParkinson Disease
InterventionOther
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The pedunculopontine tegmental nucleus (PPN) is a neurochemically heterogeneous structure located in the rostral brainstem that forms part of two important regulatory systems of behaviour: theExpand
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The historical background and more recent findings about the anatomy and function of the PPN and its implications in the basal ganglia network of the normal as well as diseased brain are summarized. Expand
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Topographical Organization of the Pedunculopontine Nucleus
TLDR
The case that the PPN should not be considered as a homogeneous structure is supported and it is concluded that the differences between rostral and caudal PPN, along with their intrinsic connectivity, may underlie the basis of its complexity. Expand
Participation of the pedunculopontine tegmental nucleus in arousal-demanding functions
The pedunculopontine tegmental nucleus (PPTg) is part of the locomotor mesencephalic region and the reticular activating system (RAS). As such, it is involved in regulating some aspects of the motorExpand
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TLDR
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