Pedigree discriminant analysis of two French Canadian Tay-Sachs families.

Abstract

Two French Canadian families among whom the Tay-Sachs allele is segregating are analyzed to investigate whether there is residual phenotypic familial covariation over and above that from major gene segregation. The traits analyzed are functions of hexosaminidase A (HEXA) and hexosaminidase B (HEXB) levels, and a combination of segregation and discriminant… (More)

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