Pediatric thyroid cancer.

@article{Sierk1990PediatricTC,
  title={Pediatric thyroid cancer.},
  author={Anne Sierk and Frederic Askin and Robert Lee Reddick and C. G. Thomas},
  journal={Pediatric pathology},
  year={1990},
  volume={10 6},
  pages={
          877-93
        }
}
A review was undertaken of the clinical, gross, and microscopic features of thyroid carcinoma in all patients younger than 21 years of age seen at North Carolina Memorial Hospital from 1952 to 1987 (N = 32). These patients had papillary carcinoma, well-differentiated follicular carcinoma with Hürthle cell change, medullary carcinoma, and an unclassifiable aggressive malignancy. In spite of the presence of lymph node metastases at diagnosis in more half the patients with papillary carcinoma, the… 
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Lymphocytic Infiltration in Pediatric Thyroid Carcinomas
  • V. Savell, S. Hughes, C. Bower, D. Parham
  • Medicine, Biology
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2004
TLDR
It is concluded that pediatric follicular carcinomas have an associated lymphocytic infiltrate in the tumor and/or adjacent thyroid, more commonly than papillary carcinomas.
pediatric versus adult papillary thyroid carcinoma: different diseases requiring different surgical approaches
TLDR
Treatment recommendations for adult thyroid cancer occasionally have been generalized to children, treating them “just like little adults,” but such extrapolations may not be warranted.
Pediatric differentiated thyroid carcinoma in stage I: risk factor analysis for disease free survival
TLDR
Male gender, tumor stage, and lymphadenopathy are risk factors for DFS in stage I pediatric DTC patients and Aggressive treatment is considered appropriate for patients with risk factors, whereas conservative or stepwise approach may be acceptable for other patients.
Pediatric thyroid cancer.
TLDR
Surgery remains the mainstay of treatment for thyroid cancer followed by radioactive iodine when appropriate, and in patients with MEN2, prophylactic thyroidectomy is recommended, although a delay in the initial diagnosis is common.
Current management of pediatric thyroid disease and differentiated thyroid cancer
TLDR
The role of ultrasound and fine needle aspiration, management of benign nodules, extent of thyroid resection, Management of regional lymph node disease, and risk stratification in staging for well differentiated thyroid cancer (DTC) in children is focused on.
Clinical features of pediatric familial non-medullary thyroid cancer (FNMTC)
TLDR
The results from the comparison of the clinical features between familial and sporadic pediatric patients affected by PTC are reported and it is debated if FNMTC has a more aggressive behavior.
Nuclear DNA analysis and prognosis in carcinoma of the thyroid gland
TLDR
It is concluded that DNA ploidy status and S-phase values are not independent prognostic factors in thyroid carcinoma.
Prognostic factors of a good response to initial therapy in children and adolescents with differentiated thyroid cancer
TLDR
Metastases, both lymph nodal and distant, are important predictors of the persistence of disease after initial therapy in children and adolescents with differentiated thyroid cancer.
Clinical characteristics, surgical approach, BRAFV600E mutation and sodium iodine symporter expression in pediatric patients with thyroid carcinoma
TLDR
It is considered important to contemplate thyroid cancer as a differential diagnosis of cervical lymph node enlargement in children, with greater female predominance, lower percentage of risk factors described and a high percentage of patients requiring aggressive surgical treatment.
Differentiated thyroid cancer in childhood: a literature update
TLDR
The clinical picture, genetic background response to treatment and recurrence rates of differentiated thyroid cancer in children and young adolescents are thoroughly reviewed and the main differences with adult differentiated Thyroid cancer are highlighted.
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References

SHOWING 1-10 OF 43 REFERENCES
Papillary carcinoma of the thyroid. A clinicopathologic study of 241 cases treated at the University of Florence, Italy
TLDR
It is concluded that conservative thyroid surgery in the form of lobectomy, without neck dissection or prophylactic administration of iodine 131 (131I), constitutes adequate therapy for most cases of papillary thyroid carcinoma.
Papillary and follicular thyroid cancer. Prognostic factors in 1,578 patients.
Thyroid cancer in children and adolescents.
TLDR
The study indicates that thyroid cancer in young patients is rather advanced at initial examination and usually associated with node and, less frequently, lung metastases and total thyroidectomy, radioiodine treatment, and thyroid suppressive therapy represent an effective combination of treatments for this disease and allow a good quality of life.
Childhood thyroid carcinoma.
TLDR
There were no deaths in those patients who underwent total thyroidectomy and appropriate regional lymph node dissection, and received therapeutic sodium iodide I 131 when indicated on the basis of follow-up scans.
Recurrence and morbidity in differentiated thyroid carcinoma in children.
TLDR
Using total or subtotal thyroidectomy or of radical neck dissection in children does not prevent recurrence and is associated with an increased risk of complications, and it is concluded that these procedures should be avoided in pediatric patients.
Thyroid cancer in children and teenagers.
TLDR
A study of thyroid cancer in patients younger than 20 years showed most tumors to be of the differentiated type, and permanent hypoparathyroidism was found in 17% of patients after total thyroidectomy.
Differentiated thyroid carcinoma in childhood: long term follow-up of 72 patients.
TLDR
The need for complete surgical treatment and compulsive follow-up should be continued throughout the patient's life, in order to detect and effectively treat relapses of thyroid cancer, is underlines.
Encapsulated Papillary Neoplasms of the Thyroid: A Study of 14 Cases Followed for a Minimum of 10 Years
  • H. Evans
  • Medicine
    The American journal of surgical pathology
  • 1987
TLDR
Fourteen cases of encapsulated papillary thyroid neoplasm in which extracapsular extension was not observed and a minimum of 10 years follow-up was available are presented and the malignant potential of this category is as yet best considered undefined.
Papillary thyroid carcinoma in children and adults: long-term follow-up of 1039 patients conservatively treated at one institution during three decades.
TLDR
PTC was more often metastatic to neck nodes and lungs before initial surgery and more often recurrent in neck lymph nodes postoperatively, and PTC tended to be less fatal in children, and this may be related to the infrequency of nondiploid DNA content in the childhood PTC tumors.
Thyroid carcinoma in children and adolescents
TLDR
At the end of the study 37 patients were alive without signs of recurrence and two patients died of metastatic tumor growth, 5 and 14 years after the primary diagnosis of thyroid carcinoma.
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