Pediatric molecular oncology. Past as prologue to the future.

  title={Pediatric molecular oncology. Past as prologue to the future.},
  author={Alfred G. Knudson},
  volume={71 10 Suppl},
The great successes in the treatment of childhood cancers have been followed in recent years with a new understanding of the molecular genetic abnormalities that underlie their origin. For some cancers these genetic changes are in oncogenes; in others, they are in antioncogenes, or tumor suppressor genes. Initiating aberrations in the former are associated characteristically with chromosomal translocations, the analysis of which should soon lead to the identification of oncogenes other than… CONTINUE READING