Pediatric idiopathic nephrotic syndrome: treatment strategies in steroid dependent and steroid resistant forms.

@article{Ulinski2010PediatricIN,
  title={Pediatric idiopathic nephrotic syndrome: treatment strategies in steroid dependent and steroid resistant forms.},
  author={T. Ulinski and B. Aoun},
  journal={Current medicinal chemistry},
  year={2010},
  volume={17 9},
  pages={
          847-53
        }
}
Idiopathic nephrotic syndrome (INS) is defined as massive proteinuria and hypoalbuminemia associated with dyslipidemia and generalized oedema in most cases. It is thought to be due to a plasma factor of immunologic origin. Most cases are steroid responsive. However, a considerable proportion of children run a steroid dependent course. Calcineurin inhibitors and alkylating agents have been classical treatment strategies for such cases, but specific toxicity limits the use of these drugs… Expand
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