Pediatric germ cell tumors presenting beyond childhood?

  title={Pediatric germ cell tumors presenting beyond childhood?},
  author={J. Wolter A. Oosterhuis and Johannes A Stoop and Martin A. Rijlaarsdam and Katharina Biermann and Vincent T. H. B. M. Smit and Remko Hersmus and Leendert H J Looijenga},
  volume={3 1},
Four cases are reported meeting the criteria of a pediatric (i.e., Type I) testicular germ cell tumor (TGCT), apart from the age of presentation, which is beyond childhood. The tumors encompass the full spectrum of histologies of pediatric TGCT: teratoma, yolk sac tumor, and various combinations of the two, and lack intratubular germ cell neoplasia/carcinoma in situ in the adjacent parenchyma. The neoplasms are (near)diploid, and lack gain of 12p, typical for seminomas and non-seminomas of the… CONTINUE READING