Pediatric adrenocortical tumors: molecular events leading to insulin-like growth factor II gene overexpression.

@article{Wilkin2000PediatricAT,
  title={Pediatric adrenocortical tumors: molecular events leading to insulin-like growth factor II gene overexpression.},
  author={Françoise Wilkin and Nancy Gagn{\'e} and Julie Paquette and Luc Laurier Oligny and Chad Deal},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2000},
  volume={85 5},
  pages={
          2048-56
        }
}
It has been previously shown that adrenocortical tumors (ACT) in adults exhibit structural abnormalities in tumor DNA in approximately 30% of cases. These abnormalities involve chromosome 11p15 and include loss of heterozygosity, paternal isodisomy, and overexpression of the gene for insulin-like growth factor II (IGF2), correlating with DNA demethylation at this locus. It has been hypothesized that these events occur late in the tumorigenic process in adults and seem to correlate with a worse… CONTINUE READING

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