Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias

@article{Mullighan2007PediatricAM,
  title={Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias},
  author={Charles G Mullighan and Alison T. Kennedy and Xuan Zhou and Ina Radtke and Letha A A Phillips and Sheila Shurtleff and James R. Downing},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={2000-2009}
}
Somatic mutations in nucleophosmin (NPM1) occur in approximately 35% of adult acute myeloid leukemia (AML). To assess the frequency of NPM1 mutations in pediatric AML, we sequenced NPM1 in the diagnostic blasts from 93 pediatric AML patients. Six cases harbored NPM1 mutations, with each case lacking common cytogenetic abnormalities. To explore the phenotype of the AMLs with NPM1 mutations, gene expression profiles were obtained using Affymetrix U133A microarrays. NPM1 mutations were associated… CONTINUE READING

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