Pediatric Zolpidem Ingestion Demonstrating Zero-Order Kinetics Treated With Flumazenil

@article{Thornton2013PediatricZI,
  title={Pediatric Zolpidem Ingestion Demonstrating Zero-Order Kinetics Treated With Flumazenil},
  author={Stephen L. Thornton and E. M. Negus and Shaun D. Carstairs},
  journal={Pediatric Emergency Care},
  year={2013},
  volume={29},
  pages={1204–1206}
}
Abstract Zolpidem is a widely prescribed anti-insomnia agent. Although most pediatric zolpidem ingestions are benign, large ingestions can cause significant central nervous system (CNS) depression. Flumazenil has been reported to reverse the CNS effects of zolpidem. We describe a case of a large pediatric zolpidem ingestion resulting in profound CNS depression that responded to flumazenil administration. Serial zolpidem serum levels confirmed the ingestion. A 10-year-old boy with trisomy 21… 
Reversal of a Suspected Paradoxical Reaction to Zopiclone with Flumazenil
TLDR
It is indicated that zopiclone induced behavioral changes resembling a paradoxical reaction to benzodiazepines and these symptoms may be treated with flumazenil.
Pediatric Sleep Pharmacology: A Primer.

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