Pediatric Tumor Cells Express Erythropoietin and a Functional Erythropoietin Receptor that Promotes Angiogenesis and Tumor Cell Survival

@article{Batra2003PediatricTC,
  title={Pediatric Tumor Cells Express Erythropoietin and a Functional Erythropoietin Receptor that Promotes Angiogenesis and Tumor Cell Survival},
  author={Sandeep Batra and Natalya Perelman and Lori R. Luck and Hiroyuki Shimada and Punam Malik},
  journal={Laboratory Investigation},
  year={2003},
  volume={83},
  pages={1477-1487}
}
Erythropoietin was traditionally considered an erythroid-restricted cytokine, but recent evidence indicates a broader role for it in nonhematopoietic tissues, specifically in neural development. Pediatric solid tumors are mostly developmental in origin, and more than 50% of the solid tumors are neural in origin. We found erythropoietin receptor and erythropoietin expression in common pediatric tumor cells: neuroblastomas, Ewing's sarcoma family of tumors, pediatric brain tumors (medulloblastoma… CONTINUE READING
Highly Cited
This paper has 115 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 59 extracted citations

Expression of erythropoietin and erythropoietin receptor in non-small cell lung carcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2005
View 4 Excerpts
Highly Influenced

116 Citations

051015'06'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 116 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 49 references

Nonerythropoietic roles of erythropoietin in the fetus and neonate.

Clinics in perinatology • 2000
View 3 Excerpts
Highly Influenced

[Intratumor pO2, S-phase fraction and p53 status in cervix carcinomas].

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] • 1997
View 4 Excerpts
Highly Influenced

Placenta growth factor is increased in sickle cell disease, activates monocytes and modulates the clinical severity of sickle cell disease

N Perelman, SK Selvaraj, +5 authors P Malik
Blood 102:1506–1514. • 2003
View 3 Excerpts

Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 1 Excerpt