Pediatric Stress: Hormonal Mediators and Human Development

@article{Charmandari2003PediatricSH,
  title={Pediatric Stress: Hormonal Mediators and Human Development},
  author={Evangelia Charmandari and Tomoshige Kino and Emmanuil Souvatzoglou and George P. Chrousos},
  journal={Hormone Research in Paediatrics},
  year={2003},
  volume={59},
  pages={161 - 179}
}
Stress activates the central and peripheral components of the stress system, i.e., the hypothalamic-pituitary-adrenal (HPA) axis and the arousal/sympathetic system. The principal effectors of the stress system are corticotropin-releasing hormone (CRH), arginine vasopressin, the proopiomelanocortin-derived peptides α-melanocyte-stimulating hormone and β-endorphin, the glucocorticoids, and the catecholamines norepinephrine and epinephrine. Appropriate responsiveness of the stress system to… 
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markdownabstractDysregulation of hypothalamic-pituitary-adrenal (HPA) axis activity can be determined by studying patterns of the diurnal cortisol rhythm. Cortisol, the end-product of the HPA axis,
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