Pediatric IBS: an overview on pathophysiology, diagnosis and treatment.

  title={Pediatric IBS: an overview on pathophysiology, diagnosis and treatment.},
  author={Ashish S Chogle and Stijn Mintjens and Miquel Saps},
  journal={Pediatric annals},
  volume={43 4},
Irritable bowel syndrome (IBS) is a common disorder in children and adults. The pathogenesis and pathophysiology of IBS remains incompletely understood. The biopsychosocial model, which conceptualizes chronic pain as a dysregulation of the gut-brain-homeostasis with peripheral and central factors mutually influencing each other, is the most accepted framework to explain IBS. Twin and family aggregation studies suggest a genetic component that does not exclusively explain the higher prevalence… CONTINUE READING