Pediatric Helicobacter pylori isolates display distinct gene coding capacities and virulence gene marker profiles.

@article{Talarico2009PediatricHP,
  title={Pediatric Helicobacter pylori isolates display distinct gene coding capacities and virulence gene marker profiles.},
  author={Sarah Talarico and Benjamin D. Gold and Jutta B Fero and Dexter T Thompson and Jeannette Guarner and Steven J. Czinn and Nina R Salama},
  journal={Journal of clinical microbiology},
  year={2009},
  volume={47 6},
  pages={1680-8}
}
Helicobacter pylori strains display remarkable genetic diversity, and the presence of strains bearing the toxigenic vacA s1 allele, a complete cag pathogenicity island (PAI), cagA alleles containing multiple EPIYA phosphorylation sites, and expressing the BabA adhesin correlates with development of gastroduodenal disease in adults. To better understand the genetic variability present among pediatric strains and its relationship to disease, we characterized H. pylori strains infecting 47… CONTINUE READING