Pediatric Formulations: Knowledge Gaps Limiting the Expedited Preclinical to Clinical Translation in Children

@article{Lavan2018PediatricFK,
  title={Pediatric Formulations: Knowledge Gaps Limiting the Expedited Preclinical to Clinical Translation in Children},
  author={Monika Lavan and Stephen Robert Byrn and Gregory T. Knipp},
  journal={AAPS PharmSciTech},
  year={2018},
  volume={20},
  pages={1-7}
}
Traditionally, drug discovery and development research have been primarily focused on the mitigation of disease treatment for the general adult population, often overlooking the medical needs of pediatric patients. While remarkable progress toward the discovery of better medicines has been made, the pharmacological differences between children and adults are often neglected as part of the translation process. In fact, until recently, children have been considered therapeutic orphans due to the… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 94 REFERENCES

regulation of gene expression, enzyme activities, and impact of genetic variation

UM Zanger, Schwab M. Cytochrome P450 enzymes in drug metabolism
  • Pharmacol Ther. 2013;138:103–41. 73 Page 7 of 7 Pediatric Formulations: Expediting Clinical Translation
  • 2019
VIEW 1 EXCERPT

The ontogeny of cytochrome P450 enzyme activity and protein abundance in conventional pigs in support of preclinical pediatric drug research

J Millecam, L De Clerck, +3 authors W Schelstraete
  • Front Pharmacol. 2018;9:470 https://www.frontiersin.org/articles/10.3389/ fphar.2018.00470/full. Accessed
  • 2018

Impaired intestinal barrier function and relapsing digestive disease: Lessons from a porcine model of early life stress.

  • Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 2017

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