Pediatric Endocrinology Update: An Overview

@article{Macgillivray1998PediatricEU,
  title={Pediatric Endocrinology Update: An Overview},
  author={M. Macgillivray and A. Morishima and F. Conte and M. Grumbach and Eric P. Smith},
  journal={Hormone Research in Paediatrics},
  year={1998},
  volume={49},
  pages={2 - 8}
}
The goals of this presentation are to review the essential roles of aromatase, estrogens and the estrogen receptor in pubertal growth. Estrogen deficiency due to mutations in the aromatase gene (CYP19) and estrogen resistance due to disruptive mutations in the estrogen receptor gene have no effect on normal male sexual maturation in puberty. However, they lead to absence of the pubertal growth spurt, delayed bone maturation, unfused epiphyses, continued growth into adulthood and very tall adult… Expand

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References

SHOWING 1-10 OF 25 REFERENCES
Clinical review 78: Aromatase deficiency in women and men: would you have predicted the phenotypes?
  • S. Bulun
  • Biology, Medicine
  • The Journal of clinical endocrinology and metabolism
  • 1996
Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man.
A new cause of female pseudohermaphroditism: placental aromatase deficiency.
Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovaries.
Four cases of pregnancy with low estrogen production due to placental enzymatic deficiency.
Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency.
...
1
2
3
...