Pediatric Endocrinology Update: An Overview

  title={Pediatric Endocrinology Update: An Overview},
  author={Margaret H Macgillivray and Akira Morishima and Felix A. Conte and Melvin M. Grumbach and Eric P. Smith},
  journal={Hormone Research in Paediatrics},
  pages={2 - 8}
The goals of this presentation are to review the essential roles of aromatase, estrogens and the estrogen receptor in pubertal growth. Estrogen deficiency due to mutations in the aromatase gene (CYP19) and estrogen resistance due to disruptive mutations in the estrogen receptor gene have no effect on normal male sexual maturation in puberty. However, they lead to absence of the pubertal growth spurt, delayed bone maturation, unfused epiphyses, continued growth into adulthood and very tall adult… 

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