Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm: A Systematic Literature Review

@article{Kim2017PediatricBP,
  title={Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm: A Systematic Literature Review},
  author={Marie Jeong-Min Kim and Ahmed Lotfy Nasr and Bilaal Kabir and J. de Nanassy and Ken Tang and Danielle Menzies-Toman and Donna L Johnston and Dina El Demellawy},
  journal={Journal of Pediatric Hematology/Oncology},
  year={2017},
  volume={39},
  pages={528–537}
}
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive hematologic malignancy characterized by frequent skin involvement that most commonly affects older patients. BPDCN is known to have a poor prognosis. Our objective was to assess if outcome and disease prognosis were independently influenced by age when evaluated with clinical presentation, sex, and treatment regimens. We conducted a systematic review to identify BPDCN cases, to compare pediatric BPDCN cases with adult… 
Pediatric blastic plasmacytoid dendritic cell neoplasm: report of four cases and review of literature
TLDR
More studies are needed to address the question whether the complex karyotype and KMT2 family genes are the causes of the relapse and refractory in BPDCN.
Blastic plasmacytoid dendritic cell neoplasm in a child: A case report of this rare entity
TLDR
A case of BPDCN is reported in an eleven years old boy presented with skin nodules on cheek and forehaed and kept on palliation to improve the knowledge of physicians regarding this rare disease.
Blastic plasmacytoid dendritic cell neoplasm with skin and bone marrow involvement: Report of three cases
BACKGROUND Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematopoietic malignancy. BPDCN is difficult to diagnose because of the overlap in morphologic and
Blastic plasmacytoid dendritic cell neoplasm. A rare hematodermic malignancy
TLDR
BPDCN is a rare form of hematological neoplasm known to arise from precursors of plasmacytoid dendritic cells (pDCs), hence the name.
Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel agents
TLDR
Advances in the understanding of the pathobiology of BPDCN and the results of early clinical studies have revealed novel targets and potentially effective agents that may improve outcomes for patients with BPD CN.
Blastic Plasmacytoid Dendritic Cell Neoplasm: First Case Report From Rwanda and Review of the Literature
TLDR
The first reported case of BPDCN is presented, to the authors' knowledge, in a Rwandan patient, and it is shown that this neoplasm is derived from plasmacytoid dendritic cells.
Blastic Plasmacytoid Dendritic Cell Neoplasm in Children.
TLDR
Treatment with high-risk acute lymphoblastic leukemia therapy regimens with central nervous system prophylaxis is recommended in pediatric patients and stem cell transplant in children is recommended for relapsed/refractory disease or high- risk disease at presentation.
Exploring the effect of chidamide on blastic plasmacytoid dendritic cell neoplasm: a case report and literature review
TLDR
A 41-year-old man who used oral chidamide 30 mg twice per week for maintenance therapy after receiving complete remission is reported, for the first time in this field, in the treatment of BPDCN.
Dendritic Cell Leukemia: a Review
TLDR
BPDCN is a rare aggressive malignancy that needs an aggressive induction therapy and a diagnostic consensus is still lacking, and large retrospective studies are also needed to obtain standardized treatment guidelines.
Blastic Plasmacytoid Dendritic Cell Neoplasm: Progress in Cell Origin, Molecular Biology, Diagnostic Criteria and Therapeutic Approaches
TLDR
In this review, a summary of the differentiation of BPDCN from its cell origin, its connection with normal pDCs, clinical characteristics, genetic mutations and advances in treatment are summarized.
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References

SHOWING 1-10 OF 173 REFERENCES
Blastic plasmacytoid dendritic cell neoplasm in children: diagnostic features and clinical implications
TLDR
In contrast to adult cases, in which long-term survival depends on stem cell transplantation in first complete remission, blastic plasmacytoid dendritic cell neoplasms in children are clinically less aggressive.
Blastic Plasmacytoid Dendritic Cell Neoplasm: A Single-Center Experience Documenting Frequent CNS Involvement
TLDR
CNS involvement with BPDCM at diagnosis may be more common than the literature suggests and should be investigated at diagnosis to allow these patients the best chance of long-term survival.
A Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child
TLDR
A 14-year-old boy with BPDCN involving the skin, bone marrow and lymph nodes achieves a complete remission after induction chemotherapy and still maintains clinical remission without HSCT for 17 months after initial diagnosis.
Blastic plasmacytoid dendritic cell neoplasm: A case report
TLDR
The case reported in the present study was characterized by rapid development and poor prognosis, and displayed additional features of BPDCN, including systemic dissemination and a short survival period.
Blastic Plasmacytoid Dendritic Cell Neoplasm in the Pediatric Population: A Case Series and Review of the Literature
TLDR
These cases contribute to the limited number of pediatric BPDCN cases, thus helping to advance the knowledge toward an optimal treatment protocol for clinical remission.
Blastic plasmacytoid dendritic cell neoplasm: report of two pediatric cases.
TLDR
Cases of two children in whom bone marrow showed infiltration by large atypical monocytoid 'blast-like' cells which on immunophenotyping expressed CD4, CD56, HLA-DR and CD33 while were negative for CD34 other T-cell, B-cell and myeloid markers are reported.
Blastic plasmacytoid dendritic cell neoplasm: a single-center experience
TLDR
Patients with BPDCN showed various clinical, histological, and immunophenotypical features and treatment outcomes were reviewed, and all four patients with cutaneous involvement survived, whereas those without skin involvement succumbed to death, even though two of them were given salvage chemotherapy.
Diffuse lung metastases in a child with blastic plasmacytoid dendritic cell neoplasm and review
TLDR
A special case of BPDCN with diffuse nodular lung metastases and a cutaneous lesion is reported, which achieved a dramatic response to non-Hodgkin lymphoma regimen and remained with complete remission for 2 years.
Blastic Plasmacytoid Dendritic Cell Neoplasm: Analysis of Clinicopathological Feature and Treatment Outcome of Seven Cases
TLDR
The aim of this study was to describe the clinical and pathological features of BPDCN, and to review the treatment courses to analyze the prognosis and the optimal therapeutic approach.
Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm: laboratory approaches in 2 cases
TLDR
2 patients with BPDCN who exhibited leukemic manifestation who were diagnosed by using immunohistochemical staining and flow cytometry analysis for CD4, CD56, and CD123 are reported.
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