Pediatric Allergic Rhinitis: Factors Affecting Treatment Choice

@article{Gelfand2005PediatricAR,
  title={Pediatric Allergic Rhinitis: Factors Affecting Treatment Choice},
  author={Erwin W Gelfand},
  journal={ENT Journal},
  year={2005},
  volume={84},
  pages={163 - 168}
}
  • E. Gelfand
  • Published 1 March 2005
  • Medicine
  • ENT Journal
Allergic rhinitis is the most prevalent chronic allergic disease in children. Although it is not life-threatening, it can have a significantly detrimental effect on a child's quality of life, and it may exacerbate a number of common comorbidities, including asthma and sinusitis. The Allergic Rhinitis and its Impact on Asthma guidelines, an evidence-based algorithm for the treatment of allergic rhinitis, advocate the use of antihistamines for the treatment of the broad spectrum of the disease… 
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References

SHOWING 1-10 OF 86 REFERENCES
Complications of allergic rhinitis.
TLDR
Allergic rhinitis is not only a very common disease process, affecting up to a cumulative frequency of 42% of the U.S. population by age 40, but can lead to significant short-term and long-term medical complications.
First do no harm: managing antihistamine impairment in patients with allergic rhinitis.
TLDR
It is recommended that primary care and specialist physicians, nurse practitioners, physician assistants, pharmacists, and all other health professionals involved in the diagnosis and treatment of allergic rhinitis follow this consensus document and share this information with patients for whom antihistamine therapy is recommended.
Safety of fexofenadine in children treated for seasonal allergic rhinitis.
TLDR
Fexofenadine, 15, 30, and 60 mg twice daily, was safe and well tolerated in this large pediatric patient population, and there was no statistically significant mean change from baseline in any electrocardiogram parameter after fexofanadine treatment.
Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis – a pooled analysis of three studies
  • E. Meltzer, P. Scheinmann, +5 authors E. Ruuth
  • Medicine
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
  • 2004
TLDR
Fexofenadine, at doses of up to 60 mg b.i.d., is safe and non‐sedating, and fexofenonadine HCl 30‚¬g b.
Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis.
TLDR
The efficacy and safety of the H(1)-antihistamine fexofenadine has been confirmed in this multicenter, multinational study of children aged 6 to 11 years with seasonal allergic rhinitis.
Cetirizine for seasonal allergic rhinitis in children aged 2‐6 years
TLDR
Cetirizine was more active than placebo for eaeh symptom evaluated both by parents and investigators, providing excellent or good improvement in 34/54 patients compared with 25/53 patients on placebo, and Toleranee was good.
Central nervous system side effects of first- and second-generation antihistamines in school children with perennial allergic rhinitis: a randomized, double-blind, placebo-controlled comparative study.
TLDR
It is shown that cetirizine has sedative properties in children and the lack of correlation between P300 latency and the visual analog scale indicates that sedation induced by these drugs may not be subjectively noted.
Assessment of quality of life in adolescents with allergic rhinoconjunctivitis: development and testing of a questionnaire for clinical trials.
TLDR
Impairment of quality of life may not be the same in the two groups and that it is appropriate to have a questionnaire specifically designed for adolescent rhinoconjunctivitis clinical trials.
Treatment of Seasonal Allergic Rhinitis in Children with Cetirizine or Chlorpheniramine: A Multicenter Study
TLDR
The efficacy and safety of cetirizine (5-10 mg in a single dose or 2 divided doses) and of an active control, chlorpheniramine (2 mg tid), were compared in children aged 6-11 years with SAR at 4 centers.
Once-Daily Cetirizine Effective in the Treatment of Seasonal Allergic Rhinitis in Children Aged 6 to 1 Years: A Randomized, Double-Blind, Placebo-Controlled Study
TLDR
Once-daily cetirizine 10 mg provides effective improvement in symptoms and is well tolerated, which did not occur with an incidence statistically different from that of placebo.
...
1
2
3
4
5
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