Pediatric Acetaminophen Overdose

@article{Isbister2001PediatricAO,
  title={Pediatric Acetaminophen Overdose},
  author={Geoffrey K. Isbister and Ian M. Whyte and Angela Dawson},
  journal={Journal of Toxicology: Clinical Toxicology},
  year={2001},
  volume={39},
  pages={169 - 170}
}

A framework and case studies for evaluation of enzyme ontogeny in children’s health risk evaluation

TLDR
A framework is proposed for introducing this information into problem formulation which combines data on enzyme ontogeny and chemical-specific TK to explore potential child/adult differences in internal dose and whether such metabolic differences may be important factors in risk evaluation.

Efficacy of intravenous paracetamol on pressor response in patients undergoing cesarean section under general anesthesia

TLDR
Administration of IV paracetamol 1 h before cesarean section has no significant effect in preventing hemodynamic changes at the time of endotracheal intubation.

Parents' childhood fever management: community survey and instrument development.

TLDR
The Parental Fever Management Scale requires further testing with different populations and in different cultures and healthcare systems to evaluate its usefulness in nursing practice and research.

Errores respecto a la intoxicación por paracetamol en menores de 6 años

TLDR
Ciertos aspectos debieran motivar the reflexión of los profesionales that participamos en el cuidado de los niños, y puede no ser del todo inocuos ya que pueden producir temblores o incomodidad.

Changes in pediatric toxic dose of acetaminophen.

Data Collection in Clinical Toxinology: Debunking Myths and Developing Diagnostic Algorithms*

  • G. Isbister
  • Biology
    Journal of toxicology. Clinical toxicology
  • 2002
TLDR
Analysis of databases created from prospective studies will not only answer questions about the effects of different species, but will ultimately allow the development of evidence-based methods to identify animals based on the circumstances and effects of bites, rather than requiring formal identification of the culprit.

Pediatric Acetaminophen Overdose: Assessing the Risk

Isbister and collegues (1) take issue with the prompt use of ipecac syrup at home to decontaminate children who ingested 150–200 mg/kg of acetaminophen as recommended in our study (2). They also

References

SHOWING 1-8 OF 8 REFERENCES

Acetaminophen overdose? A quick answer.

  • B. Rumack
  • Medicine
    The Journal of pediatrics
  • 1999

Acetaminophen poisoning and toxicity.

TLDR
Although toxicity and fatalities have occurred in the adolescent age group, only one death in younger children has been recorded and the question must be raised as to how many cases of "jaundice of unknown etiology" are actually due to this drug.

Unintentional Acetaminophen Ingestion in Children and the Potential For Hepatotoxicity

  • E. Caravati
  • Medicine
    Journal of toxicology. Clinical toxicology
  • 2000
TLDR
Children who ingest between 140–200 mg/kg of acetaminophen and demonstrate ipecac-induced emesis within 60 minutes may be safely managed at home and more clearly define referral criteria for these patients are defined.

Activated charcoal reduces the need for N-acetylcysteine treatment after acetaminophen (paracetamol) overdose.

TLDR
In patients ingesting more, activated charcoal appears to reduce the number of patients who achieve toxic acetaminophen concentrations and thus may reduce the need for treatment and hospital stay.

Paracetamol poisoning in children and hepatotoxicity.

TLDR
The margin of safety of frequent therapeutic doses of paracetamol in infants and young children to be a lot lower than previously appreciated is suggested.

Acetaminophen ingestion in childhood--cost and relative risk of alternative referral strategies.

TLDR
The data suggest that children less than six years of age who ingest pediatric acetaminophen products other than those from packages containing greater than 30 tablets or who ingest less than 200 mg/kg of an adult preparation may be safely managed at home without referral to a hospital.