Peculiarities of Herpes Simplex Virus (HSV) Transcription: An overview

  title={Peculiarities of Herpes Simplex Virus (HSV) Transcription: An overview},
  author={J{\'u}lius Raj{\vc}{\'a}ni and Vojvodov{\'a} Andrea and Re{\vz}uchov{\'a} Ingeborg},
  journal={Virus Genes},
The herpes simplex virus (HSV) has a 152 kbp dsDNA encoding probably 84 proteins. The approximate number of ORFs is 94, from which seven are doubled. The most probable number of single copy ORFs is 84 after omitting the two latency associated transcripts (LAT)/ORFs and the putative UL27.5 ORF. The high gene number creates a “crowded” genome with several overlapping transcripts. The unique long (UL) segment has at least 10 interposed ORFs, the existence of which was not obvious at first sequence… 

Transcriptional Regulation of Latency-Associated Transcripts (LATs) of Herpes Simplex Viruses

Seven novel transcription factors and their corresponding transcription regulatory sequences of HSV LATs are discovered, suggesting they are potentially functional in regulating HSV gene transcription, including LAT transcription.

Human CMV transcripts: an overview.

The human CMV genome consists of an approximately 230-kb dsDNA and is predicted to contain over 165 open reading frames and major alternately spliced mRNA species of HCMV originate primarily, but not exclusively, from the immediate early gene regions.

Searching for RNAP II on the Compact HSV-1 Genome

A collision model where the compact viral genome becomes overburdened by the high transcriptional activities at late time in HSV-1 infection, leading to arrested RNAP II complexes that then in turn, trigger a proteasome-mediated proteolysis of the polymerase to resolve stalled transcription is proposed.

Transcriptional Analysis of Latent and Inducible Kaposi's Sarcoma-Associated Herpesvirus Transcripts in the K4 to K7 Region

In vitro analysis of KSHV-infected primary effusion lymphoma cell lines in the presence of 12-O-tetradecanoylphorbol-13-acetate and phosphonoformic acid suggests that one latent transcript is coterminal with the previously annotated K3 gene encoding an ubiquitin-ligase known to downregulate major histocompatibility complex class I expression.

Long-Read Isoform Sequencing Reveals a Hidden Complexity of the Transcriptional Landscape of Herpes Simplex Virus Type 1

This work adds new insights for understanding the complexity of the pervasive transcriptional overlaps by suggesting that there is a crosstalk between adjacent and distal genes through interaction between their transcription apparatuses.

Residues of the UL25 Protein of Herpes Simplex Virus That Are Required for Its Stable Interaction with Capsids

The first 27 amino acids are essential for capsid binding of UL25, while residues 26 to 39, which are highly conserved in the UL25 homologues of other alphaherpesviruses, were found to be critical for stable capsidbinding.

In silico identification of putative promoter motifs of White Spot Syndrome Virus

The data may suggest the presence of two separate classes of late WSSV genes, one exploiting the cellular RNA polymerase II system for mRNA synthesis and the other generating messengers by a new virus-induced transcription mechanism.

Multifunctional Non-Coding RNAs Mediate Latent Infection and Recurrence of Herpes Simplex Viruses

It was showed that deleting LAT significantly reduced the latency and reactivation of HSV, providing new ideas for the future development of safe and effective HSV therapeutics, vaccines and oHSVs.

Molecular Cloning and Sequence Analysis of the UL45 Gene from Duck Enteritis Virus

An open reading frame (ORF) containing 675 nucleotides was got by sequencing the DEV gene libraries constructed by the laboratory andylogenetic analysis revealed that UL45 had a close evolutionary relationship with Mardivirus.

Cellular Protein Kinase D Modulators Play a Role during Multiple Steps of Herpes Simplex Virus 1 Egress

A more complex contribution of PKD to HSV-1 egress than originally anticipated is suggested and opens up new means to control these viruses.



ed.), Genetic Maps

  • 1992

Conservative herpesvirus genes encoding proteins common for all the herpesvirus subfamilies HSV-1 ORF/gene block CMV ORF c-HV gene block EBV ORF HHV8 ORF Protein /function

  • J Virol 65,
  • 1991