Peculiarities of Herpes Simplex Virus (HSV) Transcription: An overview

@article{Rajni2004PeculiaritiesOH,
  title={Peculiarities of Herpes Simplex Virus (HSV) Transcription: An overview},
  author={J{\'u}lius Raj{\vc}{\'a}ni and Vojvodov{\'a} Andrea and Re{\vz}uchov{\'a} Ingeborg},
  journal={Virus Genes},
  year={2004},
  volume={28},
  pages={293-310}
}
The herpes simplex virus (HSV) has a 152 kbp dsDNA encoding probably 84 proteins. The approximate number of ORFs is 94, from which seven are doubled. The most probable number of single copy ORFs is 84 after omitting the two latency associated transcripts (LAT)/ORFs and the putative UL27.5 ORF. The high gene number creates a “crowded” genome with several overlapping transcripts. The unique long (UL) segment has at least 10 interposed ORFs, the existence of which was not obvious at first sequence… 

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References

SHOWING 1-2 OF 2 REFERENCES

ed.), Genetic Maps

  • 1992

Conservative herpesvirus genes encoding proteins common for all the herpesvirus subfamilies HSV-1 ORF/gene block CMV ORF c-HV gene block EBV ORF HHV8 ORF Protein /function

  • J Virol 65,
  • 1991