Peculiar Effects of Selective Blockade of α2-Adrenoceptor Subtypes on Cardiac Chronotropy in Newborn Rats

@article{Zefirov2015PeculiarEO,
  title={Peculiar Effects of Selective Blockade of α2-Adrenoceptor Subtypes on Cardiac Chronotropy in Newborn Rats},
  author={Timur Lvovich Zefirov and L. I. Khisamieva and N. I. Ziyatdinova and A. L. Zefirov},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2015},
  volume={160},
  pages={6-8}
}
We studied the effects of selective blockade of various subtypes of α2-adrenoceptors on cardiac chronotropy in newborn rats. This period in rats is characterized by the absence of adrenergic regulation of heart function. Blockade of α2A/D- and α2B-adrenoceptors in 1-weekold rats provoked tachycardia. In contrast, blockade of α2C-adrenoceptors in newborn… CONTINUE READING