Pearson versus Spearman , Kendall ' s Tau Correlation Analysis on Structure-Activity Relationships of Biologic Active Compounds

  title={Pearson versus Spearman , Kendall ' s Tau Correlation Analysis on Structure-Activity Relationships of Biologic Active Compounds},
  author={Sorana-Daniela BOLBOAC and Lorentz J{\"a}ntschi},
A sample of sixty-seven pyrimidine derivatives with inhibitory activity on E. coli dihydrofolate reductase (DHFR) was studied by the use of molecular descriptors family on structure-activity relationships. Starting from the results obtained by applying of MDF-SAR methodology on pyrimidine derivatives and from the assumption that the measured activity (compounds’ inhibitory activity) of a biologically active compounds is a semi-quantitative outcome (can be related with the type of equipment used… CONTINUE READING
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