Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences?

  title={Peak experiences and the afterglow phenomenon: When and how do therapeutic effects of hallucinogens depend on psychedelic experiences?},
  author={Tomislav Maji{\'c} and Timo Torsten Schmidt and J{\"u}rgen Gallinat},
  journal={Journal of Psychopharmacology},
  pages={241 - 253}
Interest in the therapeutic potential of psychedelic substances has recently resumed. During an early phase of human psychedelic research, their therapeutic application in different pathologies had been suggested, and the first evidence for efficacy was provided. The range of recent clinical applications of psychedelics spans from cluster headaches and obsessive-compulsive disorder to addiction and the treatment of fear and anxiety in patients suffering from terminal illness, indicating… 

Figures and Tables from this paper

Novel Treatment Approaches for Substance Use Disorders: Therapeutic Use of Psychedelics and the Role of Psychotherapy

Purpose of Review The use of psychedelics in a therapeutical setting has been reported for the treatment of various diagnoses in recent years. However, as psychedelic substances are still commonly

Current perspectives on psychedelic therapy: use of serotonergic hallucinogens in clinical interventions

An overview of past and present models of psychedelic therapy is provided, and important considerations for future interventions incorporating the use of psychedelics in research and clinical practice are discussed.

The Potential Role of Serotonergic Hallucinogens in Depression Treatment

The reviewed studies suggest that psychedelics have great potential in depression therapy and, after addressing and overcoming the current study limitations, may be used as a novel method of treating depression in the future.

Scoping Review of Experiential Measures from Psychedelic Research and Clinical Trials.

Subjective responses to psychoactive drugs have served as intriguing windows into consciousness as well as useful predictors. Subjective reactions to psychedelic molecules are particularly

The acute effects of classic psychedelics on memory in humans

  • C. Healy
  • Psychology
  • 2021
Classic psychedelics dose-dependently impair memory task performance but may enhance autobiographical memory, which is relevant to the understanding of psychological mechanisms of action of psychedelic-assisted psychotherapy.

A potential role for psilocybin in the treatment of obsessive-compulsive disorder

  • E. Jacobs
  • Psychology, Biology
    Journal of Psychedelic Studies
  • 2020
Although the current evidence is limited, that multiple signals point in directions consistent with treatment potential, alongside the psychological and physiological safety of clinically administered psilocybin, support the expansion of research, both in animal models and in further randomized controlled trials, to properly investigate this potential.

Editorial: Hallucinogens and Entactogens: Establishing a New Class of Psychotherapeutic Drugs?

Three articles rise the fundamental question of mechanism behind therapeutic effects of hallucinogenic and entactogenic substances, which patients might benefit from these treatments and which might not, how therapeutic effects can be promoted and risks further minimized.

Hallucinogens and Their Therapeutic Use: A Literature Review

There is a need for well designed, standardized studies that demonstrate the impact of hallucinogenic substances on psychiatric conditions, as most studies suffered from small sample sizes, inconsistent measures, and poor study design.

Serotonergic hallucinogens in the treatment of anxiety and depression in patients suffering from a life-threatening disease: A systematic review




Comparison of the LSD-25 experience and delirium tremens.

In this paper the interest in lysergic acid diethylamide, or LSD-25, is not particularly in its value in psychotherapy, or with its use as an agent for investigation of psychodynamics, Rather, the interest is in developing an objective method for studying the subjective aspects of these experiences.

Hallucinogenic Drugs in Psychiatric Research and Treatment Perspectives and Prospects

  • R. Strassman
  • Psychology, Medicine
    The Journal of nervous and mental disease
  • 1995
It is critical that human hallucinogen research in the 1990s make use of state of the art methodologies, or consensually define when modifications are required, and training and supervisory issues also must be explicitly addressed.

The persistence of the subjective in neuropsychopharmacology: observations of contemporary hallucinogen research

This paper examines how subjective experience appears as epistemic object and practical problem in a psychopharmacological laboratory and points to a persistence of the subjective in contemporary neuropsychopharmacology.

Treatment of alcoholism using psychedelic drugs: a review of the program of research.

  • M. Mangini
  • Psychology
    Journal of psychoactive drugs
  • 1998
The history of one branch of psychedelic research, the therapeutic use of LSD in the treatment of alcoholism, and of the events that led to the relabeling of the "hallucinogens" as drugs of abuse are explored.

The neurobiology of psychedelic drugs: implications for the treatment of mood disorders

Recent behavioural and neuroimaging data show that psychedelics modulate neural circuits that have been implicated in mood and affective disorders, and can reduce the clinical symptoms of these disorders.

Ketamine psychedelic therapy (KPT): a review of the results of ten years of research.

A considerable increase in efficacy of the authors' standard alcoholism treatment when supplemented by ketamine psychedelic therapy (KPT) is demonstrated, and these psychological changes were shown to favor a sober lifestyle.

Serotonergic hallucinogens and emerging targets for addiction pharmacotherapies.

  • S. Ross
  • Psychology, Medicine
    The Psychiatric clinics of North America
  • 2012

The experimental use of psychedelic (LSD) psychotherapy.

The history of research with psychedelic drugs has produced a variety of methods for their use and conflicting claims about results. First came the wave of excitement among experimentalists in the

Mystical and archetypal experiences of terminal patients in DPT-assisted psychotherapy

Among the different altered states of consciousness facilitated by the administration of psychedelic drugs in a supportive setting, there are two general types of experience that appear to be of