Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice.

@article{Kajiyama2010Pdx1transfectedAT,
  title={Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice.},
  author={Hiromitsu Kajiyama and Tatsuo S. Hamazaki and Makoto Tokuhara and Shinji Masui and Koji Okabayashi and Kiyoshi Ohnuma and Shigeharu Yabe and Kazuki Yasuda and Shoichi Ishiura and Hitoshi Okochi and Makoto Asashima},
  journal={The International journal of developmental biology},
  year={2010},
  volume={54 4},
  pages={699-705}
}
Insulin-dependent diabetes mellitus (IDDM) is characterized by the rapid development of potentially severe metabolic abnormalities resulting from insulin deficiency. The transplantation of insulin-producing cells is a promising approach for the treatment of IDDM. The transcription factor pancreatic duodenal homeobox 1 (Pdx1) plays an important role in the differentiation of pancreatic beta cells. In this study, the human Pdx1 gene was transduced and expressed in murine adipose tissue-derived… CONTINUE READING
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Pdx1-ASCs differentiate into insulin-producing cells in vivo 705 similar to pancreatic islets

  • M. MARCHAND, I. S. SCHROEDER, +7 authors P. SAVATIER
  • 2009
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