Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.

  title={Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress.},
  author={Mira M. Sachdeva and Kathryn C. Claiborn and Cynthia Khoo and Juxiang Yang and David Groff and Raghavendra G Mirmira and Doris A. Stoffers},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 45},
Type 2 diabetes mellitus (T2DM) results from pancreatic beta cell failure in the setting of insulin resistance. Heterozygous mutations in the gene encoding the beta cell transcription factor pancreatic duodenal homeobox 1 (Pdx1) are associated with both T2DM and maturity onset diabetes of the young (MODY4), and low levels of Pdx1 accompany beta cell dysfunction in experimental models of glucotoxicity and diabetes. Here, we find that Pdx1 is required for compensatory beta cell mass expansion in… CONTINUE READING
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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

  • DR Laybutt
  • Diabetologia
  • 2007

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